Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9EA3C)

Drug Name

6-tert-butyl-m-cresol Drug Info

Synonyms

6-tert-Butyl-m-cresol; 2-tert-Butyl-5-methylphenol; 88-60-8; 6-tert-Butyl-3-methylphenol; 2-(tert-butyl)-5-methylphenol; m-Cresol, 6-tert-butyl-; Phenol, 2-(1,1-dimethylethyl)-5-methyl-; 5-Methyl-2-tert-butylphenol; 3-Methyl-6-tert-butylphenol; UNII-UXV32MJ2CA; 2-tert-butyl-5-methyl-phenol; 6-t-butyl-m-cresol; HSDB 5260; EINECS 201-842-3; NSC 48467; UXV32MJ2CA; 2-t-Butyl-5-methylphenol; BRN 1908225; Benzene, 1-tert-butyl-2-hydroxy-4-methyl-; 2-(1,1-DIMETHYLETHYL)-5-METHYLPHENOL; Phenol, 2-tert-butyl-5-methyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6937
CAS Number: CAS 88-60-8
TTD Drug ID: DM9EA3C

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Transient receptor potential cation channel V3 (TRPV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SAR292833	DM63QY0	Pain	MG30-MG3Z	Phase 2	[3]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[4]
diphenylboronic anhydride	DMRQZTS	Discovery agent	N.A.	Investigative	[5]
citral	DM53ZGY	Discovery agent	N.A.	Investigative	[6]
aspirin-triggered resolvin D1	DMOP941	Discovery agent	N.A.	Investigative	[7]
carvacrol	DMINM2D	Discovery agent	N.A.	Investigative	[8]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[9]
diphenyltetrahydrofuran	DMK8T61	Discovery agent	N.A.	Investigative	[5]
carveol	DMGIZ5U	Discovery agent	N.A.	Investigative	[2]
dihydrocarveol	DMS4U68	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V3 (TRPV3)	TT946IA	TRPV3_HUMAN	Activator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4111).
2	Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40.
3	Pharmacological profiling of the TRPV3 channel in recombinant and native assays. Br J Pharmacol. 2014 May;171(10):2631-44.
4	2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci. 2004 Jun 2;24(22):5177-82.
5	Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem. 2005 Apr 22;280(16):15928-41.
6	Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082.
7	17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.
8	Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35.
9	More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci. 2006 Aug;32(4):335-43.