Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9JXMD)

Drug Name

KPT-9274 Drug Info

Synonyms

Pak4-IN-1; PAK4-IN-1; 1643913-93-2; UNII-9T56TV18X7; 9T56TV18X7; SCHEMBL16345416; SCHEMBL16348032; KPT9274; EX-A563; BCP10637; KPT 9274;KPT9274; ZINC253387914; AKOS030526635; CS-5146; SB19836; PAK4-IN-1 pound KPT9274 pound(c); NCGC00484085-01; HY-12793; J-690230; 2-Propenamide, 3-(6-amino-3-pyridinyl)-N-((5-(4-((4,4-difluoro-1-piperidinyl)carbonyl)phenyl)-7-(4-fluorophenyl)-2-benzofuranyl)methyl)-, (2E)-; 4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide; (E)-3-(6-aminopyridin-3-

Indication

Disease Entry	ICD 11	Status	REF
Non-hodgkin lymphoma	2B33.5	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

PubChem CID: 117779453
CAS Number: CAS 1643913-93-2
TTD Drug ID: DM9JXMD

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting PAK-4 protein kinase (PAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PAK-4 protein kinase (PAK4)	TT7Y3BZ	PAK4_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51.