Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9K834)

Drug Name
FKB-001 Drug Info
Synonyms
FKB-001; 1-[2,2-DIFLUORO-2-(3,4,5-TRIMETHOXY-PHENYL)-ACETYL]-PIPERIDINE-2-CARBOXYLIC ACID 4-PHENYL-1-(3-PYRIDIN-3-YL-PROPYL)-BUTYL ESTER; (S)-4-phenyl-1-[3-(3-pyridyl)propyl]butyl N-[difluoro(3,4,5-trimethoxy)acetyl]-L-pipecolate; (1S)-4-phenyl-1-(3-pyridin-3-ylpropyl)butyl (2S)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate; (4S)-1-phenyl-7-(pyridin-3-yl)heptan-4-yl (2S)-1-[difluoro(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate; 1j4r; AC1L9JNT; CHEBI:39485; DB02888
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
446414
ChEBI ID
CHEBI:39485
CAS Number
CAS 251909-04-3
TTD Drug ID
DM9K834

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting FK506-binding protein 1A (FKBP1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GPI-1485 DM64ZYM Parkinson disease 8A00.0 Phase 2 [2]
SDZ-281-240 DMPZ67G Pruritus EC90 Phase 2 [3]
AP1903 DM2LU8M Transplant rejection NE84 Phase 1/2 [4]
Gpi-1046 DMD5WK4 Parkinson disease 8A00.0 Terminated [5]
MYRISTIC ACID DMYX0BL Discovery agent N.A. Investigative [5]
Heptyl-Beta-D-Glucopyranoside DMPQBN0 Discovery agent N.A. Investigative [6]
4-Hydroxy-2-Butanone DM7BQ65 Discovery agent N.A. Investigative [1]
L-709,587 DM9KCYQ Discovery agent N.A. Investigative [1]
Methyl Methylsulfinylmethyl Sulfide DMOCXLW Discovery agent N.A. Investigative [1]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
FK506-binding protein 1A (FKBP1A) TTMW94E FKB1A_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
3 Clearing of psoriasis by a novel immunosuppressive macrolide. J Invest Dermatol. 1996 Apr;106(4):701-10.
4 Using gene transfer to circumvent off-target effects. Gene Ther. 2008 May;15(10):759-64.
5 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.