Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9L1AC)

Drug Name

SYR-472 Drug Info

Synonyms

Trelagliptin succinate; TRELAGLIPTIN SUCCINATE; 1029877-94-8; Trelagliptin (succinate); UNII-4118932Z90; AK198895; 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile; 4118932Z90; SYR-472 succinate; (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile succinate; SYR 111472 succinate; Trelagliptin succinate [USAN]; SYR111472 SUCCINATE; SYR 472; SYR472; Zafatek (TN); Trelagliptin succinat; SYR472 succinate; syr; Trelagliptin Succinate

Indication

Disease Entry	ICD 11	Status	REF
Metabolic disorder	5C50-5D2Z	Phase 3	[1]
Non-insulin dependent diabetes	5A11	Investigative	[2]

Cross-matching ID

PubChem CID: 15983988
ChEBI ID: CHEBI:134715
CAS Number: CAS 865759-25-7
TTD Drug ID: DM9L1AC

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Dipeptidyl peptidase 4 (DPP-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saxagliptin	DMGXENV	Type-2 diabetes	5A11	Approved	[4]
Sitagliptin	DMGDKXN	Cystic fibrosis	CA25	Approved	[5]
Alogliptin	DM8WI3R	Type-2 diabetes	5A11	Approved	[6]
Linagliptin	DMWFJTR	Non-insulin dependent diabetes	5A11	Approved	[7]
Vildagliptin	DMYN59P	Type-2 diabetes	5A11	Approved	[8]
Dapagliflozin Propanediol; Saxagliptin Hydrochloride	DM34TXO	Type-2 diabetes	5A11	Approved	[9]
Anagliptin	DMJXIC9	Type-2 diabetes	5A11	Approved	[10]
SaxaDapa FDC	DMAPRWV	Diabetic complication	5A2Y	Phase 3	[11]
LC-150444	DM09RKB	Type-2 diabetes	5A11	Phase 3	[12]
Dutogliptin	DMM5VTA	Type-2 diabetes	5A11	Phase 3	[13]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dipeptidyl peptidase 4 (DPP-4)	TTDIGC1	DPP4_HUMAN	Inhibitor	[3]

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References

1	Clinical pipeline report, company report or official report of Takeda.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612).
3	SYR-472, a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32.
4	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
5	Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors. Pharmacol Ther. 2009 Oct;124(1):113-38.
6	Clinical pipeline report, company report or official report of Takeda (2009).
7	Boehringer Ingelheim. Product Development Pipeline. June 2 2009.
8	Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10	Diabetes Treatment. Diabetes Care. 2009 March; 32(3): e25-e30.
11	Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes. Cardiol Rev. 2010 Jul-Aug;18(4):213-7.
12	Clinical pipeline report, company report or official report of ShangHai APIs Chemical.
13	Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55.