Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9RU1U)

Drug Name
ASP8731 Drug Info
Synonyms ML-0207
Indication
Disease Entry ICD 11 Status REF
Sickle-cell disorder 3A51 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM9RU1U

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transcription regulator protein BACH1 (Bach1) TT2ME4S BACH1_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT05167526) A Phase 1 Combined Single and Multiple Ascending Oral Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP8731 in Healthy Adult Participants, Including an Assessment of a Food Effect. U.S.National Institutes of Health.
2 The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease. Front Med (Lausanne). 2023 Apr 18;10:1101501.