Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9SXMB)

Drug Name

Z-Arg-Leu-Val-Agly-Ile-Val-OMe Drug Info

Synonyms

Z-Arg-Leu-Val-Azagly-Ile-Val-OMe; CHEMBL2028907; 464883-21-4; Z-Arg-Leu-Val-Agly-Ile-Val-OMe; GTPL6534; BDBM50409586; ZINC95550984; 883Z214; methyl (2S)-2-[[(2S,3S)-2-[[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]carbamoylamino]-3-methylpentanoyl]amino]-3-methylbutanoate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10033311
TTD Drug ID: DM9SXMB

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27998201-Compound-12	DM8QZNC	Bone cancer	2B5Z	Patented	[3]
PMID27998201-Compound-5	DMVZ0ND	Chronic obstructive pulmonary disease	CA22	Patented	[3]
PMID27998201-Compound-9	DM1JOZN	Rheumatoid arthritis	FA20	Patented	[3]
PMID27998201-Compound-17	DMAZVHJ	Hair loss	ED70	Patented	[3]
PMID27998201-Compound-11	DMTV5NU	Metastatic cancer	2D50-2E2Z	Patented	[3]
PMID27998201-Compound-2	DMMAE3C	Alzheimer disease	8A20	Patented	[3]
PMID27998201-Compound-22	DMS9QA7	Alzheimer disease	8A20	Patented	[3]
PMID27998201-Compound-13	DMZHIM8	Hepatic fibrosis	DB93.0	Patented	[3]
Dimethoxybenzylidene-2-thio-imidazole-4-one derivative 1	DMZ4B3W	Cerebral ischemia	8B11	Patented	[3]
PMID27998201-Compound-24	DM25BNZ	Glioma	2A00.0	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin B (CTSB)	TTF2LRI	CATB_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6534).
2	Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11.
3	Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.