Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9SYUT)

Drug Name

PAMAPIMOD Drug Info

Synonyms

Pamapimod; 449811-01-2; RO 4402257; UNII-8S2C9V11K4; Pamapimod (R-1503, Ro4402257); CHEMBL1090089; CHEBI:90685; 8S2C9V11K4; Ro4402257; Ro-4402257; R1503; R 1503; R-1503; 6-(2,4-Difluorophenoxy)-2-{[3-Hydroxy-1-(2-Hydroxyethyl)propyl]amino}-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One; Pamapimod [USAN:INN]; 6-(2,4-Difluorophenoxy)-2-((3-hydroxy-1-(2-hydroxyethyl)propyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one; 6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 16220188
ChEBI ID: CHEBI:90685
CAS Number: CAS 449811-01-2
TTD Drug ID: DM9SYUT

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ozagrel	DMIGKA1	Xerophthalmia	5B55.Y	Phase 4	[3]
Losmapimod	DMIL37Z	Acute coronary syndrome	BA41	Phase 3	[3]
VX-702	DMKJDR6	Coronary artery disease	BA80	Phase 2a	[4]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[5]
Dilmapimod	DMBYJ92	Acute lung injury	NB32.3	Phase 2	[3]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[6]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[6]
PMID25991433-Compound-L2	DM58UO9	N. A.	N. A.	Patented	[6]
PMID25991433-Compound-L3	DM3LWUR	N. A.	N. A.	Patented	[6]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Stress-activated protein kinase 2a (p38 alpha)	TTQBR95	MK14_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018538)
2	Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem. 2010 Mar 25;53(6):2345-53.
3	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
4	Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41.
5	Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
6	c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.