Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9UMSJ)

Drug Name

AM001 Drug Info

Synonyms

MLS000562506; CHEMBL1407569; HMS2222P08; SMR000453693

Indication

Disease Entry	ICD 11	Status	REF
Actinic keratosis	EK90.0	Phase 2	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Rap guanine nucleotide exchange factor 3 (RAPGEF3)	TTOE7I0	RPGF3_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03210740) Safety and Efficacy Study of AM001 Cream in the Treatment of Actinic Keratosis. U.S. National Institutes of Health.
2	Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress. Cardiovasc Res. 2019 Oct 1;115(12):1766-1777.