Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9UZM1)

Drug Name
CCS1477 Drug Info
Synonyms
CCS-1477; CBP-IN-1; 2222941-37-7; (S)-1-(3,4-Difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1r,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one; SCHEMBL20094038; SCHEMBL21515367; SCHEMBL22134021; EX-A3687; NSC818619; NSC-818619; HY-111784; CS-0091862; (S)-1-(3,4-Difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-(trans-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Cross-matching ID
PubChem CID
134457551
TTD Drug ID
DM9UZM1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting CREB-binding protein (CREBBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
C 82 DMEWXFK Scleroderma 4A42 Phase 1/2 [3]
PRI-724 DM0HTEF Acute myeloid leukaemia 2A60 Phase 1/2 [4]
FT-7051 DMCK3OI Prostate cancer 2C82.0 Phase 1 [5]
Pyrrolo-pyrrolone derivative 6 DMBW208 N. A. N. A. Patented [6]
SGC-CBP30 DMTLRGZ Discovery agent N.A. Investigative [7]
I-CBP112 DMQX3W6 Discovery agent N.A. Investigative [8]
ischemin DMM2I9G Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting Histone acetyltransferase p300 (EP300)
Drug Name Drug ID Indication ICD 11 Highest Status REF
FT-7051 DMCK3OI Prostate cancer 2C82.0 Phase 1 [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CREB-binding protein (CREBBP) TTFRCTK CBP_HUMAN Inhibitor [2]
Histone acetyltransferase p300 (EP300) TTGH73N EP300_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT03568656) Study to Evaluate CCS1477 in Advanced Tumours. U.S. National Institutes of Health.
2 Targeting the p300/CBP Axis in Lethal Prostate Cancer. Cancer Discov. 2021 May;11(5):1118-1137.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14309-14.
5 Clinical pipeline report, company report or official report of FORMA Therapeutics.
6 BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.
7 Bromodomains and their pharmacological inhibitors. ChemMedChem. 2014 Mar;9(3):438-64.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2734).
9 A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22;18(4):531-41.