General Information of Drug (ID: DM9Y05C)

Drug Name
S-(2-Aminophenyl)-L-cysteine S,S-dioxide Drug Info
Synonyms SCHEMBL9065263
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Preclinical [1]
Cross-matching ID
PubChem CID
10263849
TTD Drug ID
DM9Y05C

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Preclinical Drug(s)
Investigative Drug(s)
Drug(s) Targeting Kynureninase (KYNU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-Amino-4-[3-hydroxyphenyl]-4-hydroxybutanoic acid DM1R3VC Breast cancer 2C60-2C65 Preclinical [3]
3,6,9,12,15-Pentaoxaheptadecane DMY8IOP Discovery agent N.A. Investigative [4]
3-methoxydesaminokynurenine DMHVIK3 Discovery agent N.A. Investigative [5]
3-Hydroxyhippuric acid DM2LBFW Discovery agent N.A. Investigative [4]
3-hydroxydesaminokynurenine DM5T6AM Discovery agent N.A. Investigative [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kynureninase (KYNU) TTWQM3J KYNU_HUMAN Inhibitor [2]

References

1 Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
2 Structure, mechanism, and substrate specificity of kynureninase. Biochim Biophys Acta. 2011 Nov;1814(11):1481-8.
3 2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. Bioorg Med Chem Lett. 2002 Feb 11;12(3):361-3.
4 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5 Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.