Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9Y3B5)

Drug Name
CMX-001 Drug Info
Synonyms
Brincidofovir; CMX001; 444805-28-1; Hexadecyloxypropyl-cidofovir; CMX 001; Hexadecyloxypropyl cidofovir; UNII-6794O900AX; 6794O900AX; HDP-Cidofovir; Cidofovir-HDP; [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid; Brincidofovir [USAN:INN]; Hexadecyloxypropyl - cidofovir; Cidofovir prodrug; HDP-HPMPC; Brincidofovir (USAN); AC1LA8GF; 3-(hexadecyloxy)propyl hydrogen ((((S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 3 [1]
Cross-matching ID
PubChem CID
483477
CAS Number
CAS 444805-28-1
TTD Drug ID
DM9Y3B5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA-dependent DNA polymerase (DPOL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DFP-14927 DMGO4XJ Solid tumour/cancer 2A00-2F9Z Phase 1 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA-dependent DNA polymerase (DPOL) TTATL6Y DPOLQ_HUMAN; DPOLN_HUMAN; DPOLB_HUMAN; DPOG2_HUMAN; DPOG1_HUMAN; DPOE2_HUMAN; DPOD4_HUMAN; DPOD1_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT02087306) Phase III, Open-labeled, Multicenter Study of the Safety and Efficacy of Brincidofovir (CMX001) in the Treatment of Early Versus Late Adenovirus Infection. U.S. National Institutes of Health.
2 Detection of Molluscum Contagiosum Virus (MCV) DNA in the Plasma of an Immunocompromised Patient and Possible Reduction of MCV DNA With CMX-001. J Infect Dis. 2012 March 1; 205(5): 794-797.
3 National Cancer Institute Drug Dictionary (drug name DFP14927).