Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA1EFL)

Drug Name

(R)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide Drug Info

Synonyms

CHEMBL572687; (R)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide; SCHEMBL1312879; QJTVTVAQRCRXSM-QGZVFWFLSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Sphingosine kinase 2 (SPHK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABC294640	DMCKPG4	Advanced solid tumour	2A00-2F9Z	Phase 3	[2]
(S)-2-amino-6-hydroxy-N-(4-octylphenyl)hexanamide	DMG0CSZ	Discovery agent	N.A.	Investigative	[1]
(R)-2-amino-3-(4-octylphenylamino)propan-1-ol	DMZXT34	Discovery agent	N.A.	Investigative	[1]
ROMe	DMAROW1	Discovery agent	N.A.	Investigative	[3]
DIMETHYLSPINGOSINE	DM1OKN0	N. A.	N. A.	Investigative	[4]
(S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide	DM8A1HG	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Discovery of novel sphingosine kinase 1 inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6119-21.
2	Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.
3	(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal. 2011 Oct;23(10):1590-5.
4	Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J Med Chem. 2009 Jun 25;52(12):3618-26.