General Information of Drug (ID: DMA3FZR)

Drug Name
Carbodine Drug Info
Synonyms
Carbocyclic cytidine; 4-amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidin-2-one; 71184-20-8; (-)-Carbodine; (+/-)-Carbodine; AC1LA1FO; C-ARC-C; SCHEMBL3333453; CHEMBL1089302; 2(1H)-Pyrimidinone, 4-amino-1-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-, (2:1),(1alpha,2beta,3beta, 4alpha)-(+/-)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
459903
TTD Drug ID
DMA3FZR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting CTP synthase (CTPS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cyclopentenylcytosine DMAWVTX Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Acivicin DMPQZ80 N. A. N. A. Discontinued in Phase 3 [3]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [4]
Cyclopentylcytosine DM4KZ1W Discovery agent N.A. Investigative [2]
Cylopentenyl cytosine DMQWLIC Discovery agent N.A. Investigative [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CTP synthase (CTPS1) TTN12BZ PYRG1_HUMAN Inhibitor [1]

References

1 Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase. Mol Pharmacol. 1987 Aug;32(1):286-92.
2 Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.
3 Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Sep;41(9 Pt 1):3419-23.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Comments on: cylopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. A.C. Verschuur et al. Eur J Cancer 2000, 36, 627-635. Eur J Cancer. 2001 Jan;37(2):290.