Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA3OI4)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting NAD-dependent deacetylase sirtuin-2 (SIRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BDBM50363780	DM46UPM	N. A.	N. A.	Patented	[2]
BDBM50363782	DMUQI15	N. A.	N. A.	Patented	[2]
AC1LFGWU	DMXI3O0	N. A.	N. A.	Patented	[3]
ZINC915379	DMW9P6U	N. A.	N. A.	Patented	[3]
US9359293, TM	DM0NIB5	N. A.	N. A.	Patented	[1]
BDBM50363773	DM7TASJ	N. A.	N. A.	Patented	[2]
US9359293, TB	DMRQ2G4	N. A.	N. A.	Patented	[1]
AC1LOJYQ	DMVX9NK	N. A.	N. A.	Patented	[3]
AGK2	DM26AMU	Discovery agent	N.A.	Investigative	[4]
INDUS-815C	DMLJ645	Retinopathy	9B71	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
NAD-dependent deacetylase sirtuin-2 (SIRT2)	TTLKF5M	SIR2_HUMAN	Inhibitor	[1]

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References

1	Methods of treatment using modulators of SIRT2. US9359293.
2	Aroyl thiourea derivatives. US9365508.
3	Small molecule activators of NRF2 pathway. US9737525.
4	Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007 Jul 27;317(5837):516-9.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2708).