Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA46S1)

• Drug Name: ISIS 183883 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DMA46S1

Molecule-Related Drug Atlas

Drug(s) Targeting Kinesin spindle messenger RNA (KIF11 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALN-VSP	DM89DHO	Liver cancer	2C12	Phase 1	[2]
EMD-534085	DMQ6YAZ	Haematological malignancy	2B33.Y	Phase 1	[3]
N-[4'-(trifluoromethyl)-4-biphenylyl]thiourea	DMPVKWG	Discovery agent	N.A.	Investigative	[4]
N-[3'-(trifluoromethyl)-4-biphenylyl]urea	DM7OA4R	Discovery agent	N.A.	Investigative	[4]
4'-(trifluoromethyl)-4-biphenylsulfonamide	DMLP67R	Discovery agent	N.A.	Investigative	[4]
N-(4'-chloro-4-biphenylyl)methanesulfonamide	DM0ARP8	Discovery agent	N.A.	Investigative	[4]
ISIS 183881	DMOU9EP	Discovery agent	N.A.	Investigative	[5]
ISIS 183911	DMTB350	Discovery agent	N.A.	Investigative	[1]
4'-(trifluoromethyl)-4-biphenylyl carbamate	DMT3BX9	Discovery agent	N.A.	Investigative	[4]
ISIS 183910	DMMQ2L7	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kinesin spindle messenger RNA (KIF11 mRNA)	TTBGTCW	KIF11_HUMAN	Not Available	[1]

References

• [1] US patent application no. 7,163,927, Antisense modulation of kinesin-like 1 expression.
• [2] Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011).
• [3] The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5.
• [4] Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52.
• [5] US patent application no. 7,407,943, Antisense modulation of apolipoprotein B expression.