General Information of Drug (ID: DMA7L3O)

Drug Name
Anti-CEA CAR-T cells Drug Info
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 1 [1]
Colorectal cancer 2B91.Z Phase 1 [2]
Gastric adenocarcinoma 2B72 Phase 1 [2]
Pancreatic cancer 2C10 Phase 1 [2]
Peritoneal metastasis 2D91 Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMA7L3O

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SAR408701 DMXGE3O Non-small-cell lung cancer 2C25.Y Phase 3 [3]
Tusamitamab ravtansine DMMPSA1 Non-small-cell lung cancer 2C25 Phase 3 [4]
IDM-2101 DMABRXY Colorectal cancer 2B91.Z Phase 2 [5]
CAP1-6D DMEYIVW Pancreatic cancer 2C10 Phase 2 [6]
Pentacea DMGY5JC Small-cell lung cancer 2C25.Y Phase 2 [7]
GI-6207 DM72O6F Thyroid cancer 2D10 Phase 2 [8]
CeaVac DM6Z9BV Colorectal cancer 2B91.Z Phase 2 [9]
Labetuzumab I-131 DMNO5UE Colorectal cancer 2B91.Z Phase 2 [10]
AVX701 DMOPVIQ Colorectal cancer 2B91.Z Phase 1/2 [11]
CT84.66 DM6078F Breast cancer 2C60-2C65 Phase 1/2 [12]
SAR408701 DMXGE3O Non-small-cell lung cancer 2C25.Y Phase 3 [3]
Tusamitamab ravtansine DMMPSA1 Non-small-cell lung cancer 2C25 Phase 3 [4]
IDM-2101 DMABRXY Colorectal cancer 2B91.Z Phase 2 [5]
CAP1-6D DMEYIVW Pancreatic cancer 2C10 Phase 2 [6]
Pentacea DMGY5JC Small-cell lung cancer 2C25.Y Phase 2 [7]
GI-6207 DM72O6F Thyroid cancer 2D10 Phase 2 [8]
CeaVac DM6Z9BV Colorectal cancer 2B91.Z Phase 2 [9]
Labetuzumab I-131 DMNO5UE Colorectal cancer 2B91.Z Phase 2 [10]
AVX701 DMOPVIQ Colorectal cancer 2B91.Z Phase 1/2 [11]
CT84.66 DM6078F Breast cancer 2C60-2C65 Phase 1/2 [12]
⏷ Show the Full List of 20 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carcinoembryonic antigen CEA (CD66e) TTY6DTE CEAM5_HUMAN CAR-T-Cell-Therapy [1]

References

1 ClinicalTrials.gov (NCT02416466) CAR-T Hepatic Artery Infusions and Sir-Spheres for Liver Metastases
2 ClinicalTrials.gov (NCT03682744) CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC)
3 ClinicalTrials.gov (NCT02187848) Evaluation of SAR408701 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
4 Safety, pharmacokinetics, and antitumor activity of the anti-CEACAM5-DM4 antibody-drug conjugate tusamitamab ravtansine (SAR408701) in patients with advanced solid tumors: first-in-human dose-escalation study. Ann Oncol. 2022 Apr;33(4):416-425.
5 Induction of immune responses and clinical efficacy in a phase II trial of IDM-2101, a 10-epitope cytotoxic T-lymphocyte vaccine, in metastatic non-small-cell lung cancer. J Clin Oncol. 2008 Sep 20;26(27):4418-25.
6 Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res. 1997 Oct 15;57(20):4570-7.
7 Antibody fragments: Hope and hype. MAbs. 2010 Jan-Feb; 2(1): 77-83.
8 Clinical pipeline report, company report or official report of GlobeImmune.
9 Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen. J Clin Oncol. 1999 Sep;17(9):2889-5.
10 National Cancer Institute Drug Dictionary (drug id 692828).
11 Viral vector-based therapeutic cancer vaccines. Cancer J. 2011 Sep-Oct;17(5):359-71.
12 Technology evaluation: cT84.66, City of Hope. Curr Opin Mol Ther. 2004 Feb;6(1):90-5.