Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA971L)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Bacterial Isoleucyl-tRNA synthetase (Bact ileS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mupirocin	DMWX683	Bacterial infection	1A00-1C4Z	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Isoleucyl-tRNA synthetase (Bact ileS)	TT6KYJ5	SYI_ECOLI	Inhibitor	[1]
Isoleucyl-tRNA synthetase (IARS)	TTYD3AN	SYIC_HUMAN	Inhibitor	[2]

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References

1	Chemical modification of reveromycin A and its biological activities. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3363-6.
2	Synthesis and biological activities of reveromycin A and spirofungin A derivatives. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3756-60.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.