Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA9CZV)

Drug Name

E-003 Drug Info

Synonyms

Bcl-xL modulators (oral, cancer); Ensemblin macrocycle (oral, cancer), Ensemble Therapeutics; Bcl-xL modulators (oral, cancer), Ensemble

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Apoptosis regulator Bcl-xL (BCL-xL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABT-263	DMNE56X	Myelofibrosis	2A20.2	Phase 3	[2]
Obatoclax	DMPF9ZM	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
APG-1252	DM8O3R9	Small-cell lung cancer	2C25.Y	Phase 1/2	[4]
AZD0466	DMWLZI6	Hematologic tumour	2B33.Y	Phase 1/2	[5]
PMID27744724-Compound-18	DM73S2C	N. A.	N. A.	Patented	[6]
Indole-based analog 2	DM0NEVC	N. A.	N. A.	Patented	[6]
PMID27744724-Compound-10	DMFKS2P	N. A.	N. A.	Patented	[6]
PMID27744724-Compound-21	DM18UA5	N. A.	N. A.	Patented	[6]
Indole-based analog 3	DMTEYQJ	N. A.	N. A.	Patented	[6]
PMID27744724-Compound-26	DM8GOH3	N. A.	N. A.	Patented	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis regulator Bcl-xL (BCL-xL)	TTU1E82	B2CL1_HUMAN	Modulator	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2845).
2	Clinical pipeline report, company report or official report of Roche (2009).
3	Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
4	Bcl-2/Bcl-xl inhibitor APG-1252-M1 is a promising therapeutic strategy for gastric carcinoma. Cancer Med. 2020 Jun;9(12):4197-4206.
5	Design and optimisation of dendrimer-conjugated Bcl-2/x L inhibitor, AZD0466, with improved therapeutic index for cancer therapy. Commun Biol. 2021 Jan 25;4(1):112.
6	Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.