Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA9MBR)

Drug Name

PF-04523655 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diabetic macular edema	9B71.02	Phase 2	[1]

Therapeutic Class

siRNA

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-1 responsive protein RTP801 (DDIT4)	TT0AWFK	DDIT4_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT01445899) PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME). U.S. National Institutes of Health.
2	Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6.