Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMACYPW)

• Drug Name: ACAA Drug Info
• Synonyms: ACA

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5353376
  ChEBI ID: CHEBI:114200
  CAS Number: CAS 99196-74-4
  TTD Drug ID: DMACYPW

Molecule-Related Drug Atlas

Drug(s) Targeting Short transient receptor potential channel 3 (TRPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[6]
OAG	DMOP8IJ	Discovery agent	N.A.	Investigative	[7]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[4]
BTP2	DMNM63G	Discovery agent	N.A.	Investigative	[8]
Pyr3	DM3VNYQ	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[10]
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[12]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[13]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[14]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[15]
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[14]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[3]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[14]
linalool	DMGZQ5P	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting Long transient receptor potential channel 2 (TRPM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[17]
NAADP	DM51DW6	Discovery agent	N.A.	Investigative	[18]
OAADPR	DM458IH	Discovery agent	N.A.	Investigative	[19]
ADP ribose	DMQ1F7J	Discovery agent	N.A.	Investigative	[20]
GEA 3162	DMBGWEK	Discovery agent	N.A.	Investigative	[21]
cADPR	DMLKZQH	Discovery agent	N.A.	Investigative	[18]

Drug(s) Targeting Short transient receptor potential channel 6 (TRPC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[5]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[5]
OAG	DMOP8IJ	Discovery agent	N.A.	Investigative	[7]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[5]
flufenamate	DMN8AP0	Discovery agent	N.A.	Investigative	[5]
SAG	DMHOG7W	Discovery agent	N.A.	Investigative	[7]
ML9	DMP13VE	Discovery agent	N.A.	Investigative	[5]
hyp 9	DM0U8IV	Discovery agent	N.A.	Investigative	[22]
SLG	DMEBPCO	Discovery agent	N.A.	Investigative	[7]
20-HETE	DM5BAJ9	Discovery agent	N.A.	Investigative	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Long transient receptor potential channel 2 (TRPM2)	TTEBMN7	TRPM2_HUMAN	Blocker (channel blocker)	[2]
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Blocker (channel blocker)	[3]
Short transient receptor potential channel 3 (TRPC3)	TTNVC34	TRPC3_HUMAN	Blocker (channel blocker)	[4]
Short transient receptor potential channel 6 (TRPC6)	TTRBT3W	TRPC6_HUMAN	Blocker (channel blocker)	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2443).
• [2] Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488).
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
• [6] Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Mol Pharmacol. 2005 Sep;68(3):758-62.
• [7] Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63.
• [8] A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem. 2005 Mar 25;280(12):10997-1006.
• [9] Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.
• [10] TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
• [11] Best of the 2009 AUA Annual Meeting: Highlights from the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL. Rev Urol. 2009 Spring; 11(2): 82-107.
• [12] Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69.
• [13] Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol. Neurochem Res. 2012 Feb;37(2):314-20.
• [14] 5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9.
• [15] Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29;4(5):e5741.
• [16] Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.
• [17] Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol. 2008 Mar;153(6):1324-30.
• [18] Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J. 2006 May;20(7):962-4.
• [19] Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem. 2006 May 19;281(20):14057-65.
• [20] ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature. 2001 May 31;411(6837):595-9.
• [21] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 494).
• [22] Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77.