General Information of Drug (ID: DMAEK3L)

Drug Name
PF-05082566 Drug Info
Indication
Disease Entry ICD 11 Status REF
Non-hodgkin lymphoma 2B33.5 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMAEK3L

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Urelumab DM6RTVG B-cell non-hodgkin lymphoma 2B33.5 Phase 2 [2]
Anti-CD137 DMHVZ27 Solid tumour/cancer 2A00-2F9Z Phase 2 [4]
MG7-CART DME6PB0 Acute myeloid leukaemia 2A60 Phase 1/2 [5]
NM21-1480 DMDNJP5 Advanced solid tumour 2A00-2F9Z Phase 1/2 [6]
CD137 CAR-T Cell DMHMC19 Acute lymphoblastic leukaemia 2A85 Phase 1/2 [7]
ADG106 DM87H0S Non-hodgkin lymphoma 2B33.5 Phase 1/2 [8]
CD28 and CD137 CAR-T Cells DMFGQXB Acute lymphoblastic leukaemia 2A85 Phase 1 [9]
MCLA-145 DM8CGUV Lymphoma 2A80-2A86 Phase 1 [10]
GEN1046 DMEWRNZ Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
INBRX-105 DM2FH10 Solid tumour/cancer 2A00-2F9Z Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Co-stimulatory molecule 4-1BB (CD137) TTPW9LJ TNR9_HUMAN Modulator [3]

References

1 ClinicalTrials.gov (NCT02179918) A Study Of 4-1BB Agonist PF-05082566 Plus PD-1 Inhibitor MK-3475 In Patients With Solid Tumors (B1641003/KEYNOTE-0036). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity. Cancer Immunol Immunother. 2012 Oct;61(10):1721-33.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1878).
5 ClinicalTrials.gov (NCT02862704) A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART)
6 Clinical pipeline report, company report or official report of Numab Therapeutics.
7 ClinicalTrials.gov (NCT02965092) CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies
8 Clinical pipeline report, company report or official report of Adagene.
9 ClinicalTrials.gov (NCT02186860) Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With Acute Lymphoblastic Leukemia
10 Clinical pipeline report, company report or official report of Merus.
11 Clinical pipeline report, company report or official report of Genmab.
12 Clinical pipeline report, company report or official report of Inhibrx.