Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAFUHK)

Drug Name

QGC-001 Drug Info

Synonyms

QGC001

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Glutamyl aminopeptidase (ENPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KELATORPHAN	DMOX8FD	Discovery agent	N.A.	Investigative	[4]
PMID10602705C40	DMLH73O	Discovery agent	N.A.	Investigative	[5]
EC33	DM67549	Discovery agent	N.A.	Investigative	[6]
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Drug(s) Targeting Aspartyl aminopeptidase (DNPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID1738140C9	DM4BZ2L	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aspartyl aminopeptidase (DNPEP)	TTGMFY7	DNPEP_HUMAN	Inhibitor	[2]
Glutamyl aminopeptidase (ENPEP)	TT9PBIL	AMPE_HUMAN	Inhibitor	[3]

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References

1	ClinicalTrials.gov (NCT02322450) Phase IIa Study of the Product QGC001 Compared With Placebo in Patients With Essential Hypertension. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of Quantum Genomics.
4	Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31.
5	Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J Med Chem. 1999 Dec 16;42(25):5197-211.
6	Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem Soc Trans. 2000;28(4):435-40.
7	Alpha-Keto amide inhibitors of aminopeptidases. J Med Chem. 1992 Feb 7;35(3):451-6.