Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAG6BV)

Drug Name
LGK974 Drug Info
Synonyms
1243244-14-5; LGK974; LGK-974; 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide; WNT-974; LGK 974; UNII-U27F40013Q; CHEBI:78030; CHEMBL3188386; U27F40013Q; AK165831; 2-(2',3-dimethyl-2,4'-bipyridin-5-yl)-N-[5-(pyrazin-2-yl)pyridin-2-yl]acetamide; MLS006011002; SCHEMBL1723611; KS-00000SUI; MolPort-029-945-290; HMS3653G11; BCP08495; EX-A1402; ZINC95930187; STL556617; BDBM50133870; BBL102809; 2140AH; s7143; AKOS025211913; SB19314; CS-2807; DB12561; NCGC00347950-07; NCGC00347950-01; OR302651; QC-11701
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
PubChem CID
46926973
ChEBI ID
CHEBI:78030
CAS Number
CAS 1243244-14-5
TTD Drug ID
DMAG6BV

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Protein-serine O-palmitoleoyltransferase porcupine (PORCN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ETC-1922159 DMY0HU6 Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
RXC006 DM9LUTV Idiopathic pulmonary fibrosis CB03.4 Phase 1 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein-serine O-palmitoleoyltransferase porcupine (PORCN) TTNFBTO PORCN_HUMAN Inhibitor [2]

References

1 Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of Redx