Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAM4FE)

Drug Name

2-Ethoxypropanoic acid Drug Info

Synonyms

2-ethoxypropanoic acid; 53103-75-6; 2-ethoxypropionic acid; MFCD09940775; Propanoic acid, 2-ethoxy-; SCHEMBL142064; DTXSID00570733; 2-Ethoxypropanoic acid, AldrichCPR; STL508457; AKOS000184266; AKOS016903919; MCULE-2185795311; SY040144; DB-104575; EN300-39488; Y-6023

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Preclinical	[1]

Cross-matching ID

PubChem CID: 15268841
CAS Number: CAS 53103-75-6
TTD Drug ID: DMAM4FE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Cryptochrome circadian clock 1 (CRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KL001	DMHX1LA	Glioblastoma of brain	2A00.00	Preclinical	[3]
SHP656	DM8DYJQ	Glioblastoma of brain	2A00.00	Preclinical	[1]
TH301	DM4BDGW	Glioblastoma of brain	2A00.00	Preclinical	[1]
KL044	DMG3FDE	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting Cryptochrome-2 (CRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KL001	DMHX1LA	Glioblastoma of brain	2A00.00	Preclinical	[3]
SHP656	DM8DYJQ	Glioblastoma of brain	2A00.00	Preclinical	[1]
TH301	DM4BDGW	Glioblastoma of brain	2A00.00	Preclinical	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cryptochrome circadian clock 1 (CRY1)	TT5MLZR	CRY1_HUMAN	Inhibitor	[2]
Cryptochrome-2 (CRY2)	TTAO58M	CRY2_HUMAN	Inhibitor	[2]

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References

1	Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
2	The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55.
3	Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7.
4	Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97.