Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMANRGW)

• Drug Name: IP10 C8 Drug Info
• Synonyms: IP10C8

Indication

Disease Entry	ICD 11	Status	REF
Psoriasis vulgaris	EA90	Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DMANRGW

Molecule-Related Drug Atlas

Drug(s) Targeting Dipeptidyl peptidase 4 (DPP-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saxagliptin	DMGXENV	Type-2 diabetes	5A11	Approved	[2]
Sitagliptin	DMGDKXN	Cystic fibrosis	CA25	Approved	[3]
Alogliptin	DM8WI3R	Type-2 diabetes	5A11	Approved	[4]
Linagliptin	DMWFJTR	Non-insulin dependent diabetes	5A11	Approved	[5]
Vildagliptin	DMYN59P	Type-2 diabetes	5A11	Approved	[6]
Dapagliflozin Propanediol; Saxagliptin Hydrochloride	DM34TXO	Type-2 diabetes	5A11	Approved	[7]
Anagliptin	DMJXIC9	Type-2 diabetes	5A11	Approved	[8]
SaxaDapa FDC	DMAPRWV	Diabetic complication	5A2Y	Phase 3	[9]
LC-150444	DM09RKB	Type-2 diabetes	5A11	Phase 3	[10]
Dutogliptin	DMM5VTA	Type-2 diabetes	5A11	Phase 3	[11]

Drug(s) Targeting Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[(125)I] RB129	DMX0G7E	Discovery agent	N.A.	Investigative	[12]
KELATORPHAN	DMOX8FD	Discovery agent	N.A.	Investigative	[13]
(1-Amino-3-phenyl-propyl)-phosphinic acid	DMXD697	Discovery agent	N.A.	Investigative	[14]
N1-(3,3-diphenylpropyl)-N3-hydroxymalonamide	DM5F04D	Discovery agent	N.A.	Investigative	[15]
N1-(4-chlorobenzyl)-2-benzyl-N3-hydroxymalonamide	DMTMDZ4	Discovery agent	N.A.	Investigative	[15]
N1,2-dibenzyl-N3-hydroxy-N1-phenethylmalonamide	DM1L89K	Discovery agent	N.A.	Investigative	[15]
1-aminohexylphosphonic acid	DMFUABI	Discovery agent	N.A.	Investigative	[16]
(S)-2-Amino-3-phenyl-propane-1-thiol	DMMAUKO	Discovery agent	N.A.	Investigative	[14]
(Amino-phenyl-methyl)-phosphinic acid	DMS4ZVK	Discovery agent	N.A.	Investigative	[14]
1-aminohexylphosphonic acid monophenyl ester	DML6UJM	Discovery agent	N.A.	Investigative	[16]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aminopeptidase N (ANPEP)	TTPHMWB	AMPN_HUMAN	Modulator	[1]
Dipeptidyl peptidase 4 (DPP-4)	TTDIGC1	DPP4_HUMAN	Modulator	[1]

References

• [1] Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med. 2009;47(3):253-61.
• [2] Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
• [3] Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors. Pharmacol Ther. 2009 Oct;124(1):113-38.
• [4] Clinical pipeline report, company report or official report of Takeda (2009).
• [5] Boehringer Ingelheim. Product Development Pipeline. June 2 2009.
• [6] Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.
• [7] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [8] Diabetes Treatment. Diabetes Care. 2009 March; 32(3): e25-e30.
• [9] Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes. Cardiol Rev. 2010 Jul-Aug;18(4):213-7.
• [10] Clinical pipeline report, company report or official report of ShangHai APIs Chemical.
• [11] Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55.
• [12] Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography. Biochimie. 2004 Feb;86(2):105-13.
• [13] Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31.
• [14] Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6.
• [15] Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34.
• [16] New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6.