Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAROW1)

• Drug Name: ROMe Drug Info
• Synonyms: (R)-FTY720-OMe

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 71458556
  TTD Drug ID: DMAROW1

Molecule-Related Drug Atlas

Drug(s) Targeting Sphingosine kinase 2 (SPHK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABC294640	DMCKPG4	Advanced solid tumour	2A00-2F9Z	Phase 3	[3]
(R)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide	DMA1EFL	Discovery agent	N.A.	Investigative	[4]
(S)-2-amino-6-hydroxy-N-(4-octylphenyl)hexanamide	DMG0CSZ	Discovery agent	N.A.	Investigative	[4]
(R)-2-amino-3-(4-octylphenylamino)propan-1-ol	DMZXT34	Discovery agent	N.A.	Investigative	[4]
DIMETHYLSPINGOSINE	DM1OKN0	N. A.	N. A.	Investigative	[5]
(S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide	DM8A1HG	Discovery agent	N.A.	Investigative	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine kinase 2 (SPHK2)	TTCN0M9	SPHK2_HUMAN	Inhibitor	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6625).
• [2] (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal. 2011 Oct;23(10):1590-5.
• [3] Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.
• [4] Discovery of novel sphingosine kinase 1 inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6119-21.
• [5] Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J Med Chem. 2009 Jun 25;52(12):3618-26.