Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMASQV4)

• Drug Name: SB-611812 Drug Info
• Synonyms: SB611812

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10278166
  TTD Drug ID: DMASQV4

Molecule-Related Drug Atlas

Drug(s) Targeting Urotensin II receptor (UTS2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK1440115	DMEJMTR	Asthma	CA23	Phase 1	[3]
SB-436811	DMLPB0X	Asthma	CA23	Phase 1	[4]
PALOSURAN	DMWCLZ6	Renal failure	GB60-GB6Z	Discontinued in Phase 2	[4]
SAR101099	DMIZ7Q4	Diabetic nephropathy	GB61.Z	Discontinued in Phase 1	[5]
ICI-199441	DMEWZ80	Discovery agent	N.A.	Investigative	[6]
SB-328872	DMT1KFL	Discovery agent	N.A.	Investigative	[7]
Ac-[CFWKFC]-NH2	DM9IN4T	Discovery agent	N.A.	Investigative	[4]
Ac-FWKY-NH2	DM3XHIY	Discovery agent	N.A.	Investigative	[4]
Ac-[CFWkYC]-NH2	DMW24UH	Discovery agent	N.A.	Investigative	[4]
urotensin II-related peptide	DMCE3PJ	Discovery agent	N.A.	Investigative	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Urotensin II receptor (UTS2R)	TTW5UDX	UR2R_HUMAN	Antagonist	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3531).
• [2] A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker. J Mol Cell Cardiol. 2005 Nov;39(5):785-91.
• [3] Effects of Urotensin II Receptor Antagonist, GSK1440115, in Asthma. Front Pharmacol. 2013; 4: 54.
• [4] Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 365).
• [6] Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3716-9.
• [7] Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3950-4.
• [8] Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem Biophys Res Commun. 2003 Oct 24;310(3):860-8.