General Information of Drug (ID: DMAUG0L)

Drug Name
L-739749 Drug Info
Synonyms
CHEMBL99645; BDBM50059867; (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyloxy]-3-phenyl-propionylamino}-4-methanesulfonyl-butyric acid methyl ester; (S)-methyl 2-((S)-2-((2S,3R)-2-((R)-2-amino-3-mercaptopropylamino)-3-methylpentyloxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoate
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Terminated [1]
Cross-matching ID
PubChem CID
158357
CAS Number
CAS 156511-34-1
TTD Drug ID
DMAUG0L

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-745631 DM4UP7R Solid tumour/cancer 2A00-2F9Z Terminated [2]
ABT-839 DM4UN9A Non-small-cell lung cancer 2C25.Y Terminated [3]
MANUMYCIN A DM1SWOY N. A. N. A. Terminated [4]
SCH-44342 DMUL4VX N. A. N. A. Terminated [2]
RPR-113829 DMJ63GW N. A. N. A. Terminated [5]
RPR-114334 DMAIJT6 N. A. N. A. Terminated [5]
L-731735 DM1XBKC Solid tumour/cancer 2A00-2F9Z Terminated [2]
FUSIDIENOL DMI1Y92 N. A. N. A. Terminated [6]
ABT-100 DMPFLS5 Solid tumour/cancer 2A00-2F9Z Terminated [7]
B-956 DM1IO9X Solid tumour/cancer 2A00-2F9Z Terminated [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CAAX farnesyltransferase beta (FNTB) TT7WZIJ FNTB_HUMAN Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004259)
2 Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90.
3 Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.
4 A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett. 2003 May 5;13(9):1523-6.
5 Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase. J Med Chem. 1997 Jun 6;40(12):1763-7.
6 Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. J Med Chem. 2002 Mar 28;45(7):1460-5.
7 Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. J Heart Lung Transplant. 2005 Sep;24(9):1403-9.
8 Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res. 1995 Nov 15;55(22):5310-4.