Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAUILH)

Drug Name
DecRVKRCMK Drug Info
Indication
Disease Entry ICD 11 Status REF
Coronavirus infection 1D92 Preclinical [1]
Cross-matching ID
TTD Drug ID
DMAUILH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Dibasic-processing enzyme (Furin)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US9266828, E DMYUL2X N. A. N. A. Patented [3]
US9266828, C DMQEL1W N. A. N. A. Patented [3]
US9266828, B DMYUDCE N. A. N. A. Patented [3]
furin inhibitor peptide DM78NOM Discovery agent N.A. Investigative [4]
peptide 18 DMIDP1R Discovery agent N.A. Investigative [5]
MI-1148 DMCN91V Discovery agent N.A. Investigative [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dibasic-processing enzyme (Furin) TTH9WF6 FURIN_HUMAN Inhibitor [2]

References

1 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
2 Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses. 2019 Oct 31;11(11):1011.
3 Inhibitors of Furin and other pro-protein convertases. US9266828.
4 Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53.
5 Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109.
6 Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem. 2015 Jul;10(7):1218-31.