Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAWVTX)

Drug Name

Cyclopentenylcytosine Drug Info

Synonyms

cyclopentenyl cytosine; 90597-22-1; NSC-375575; CPE-C; UNII-69MO0NDN8K; NSC 375575; NSC375575; BRN 4258358; 69MO0NDN8K; CHEMBL63647; 1-((1R,2S,3R)-4-Hydroxymethyl-2,3-dihydroxy-4-cyclopenten-1-yl)cytosine; 4-amino-1-[(1R,4R,5S)-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2-one; 4-amino-1-[(1r,4r,5s)-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2(1h)-one; CPE-cytosine; 2(1H)-Pyrimidinone, 4-amino-1-((1R,4R,5S)-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl)-

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

PubChem CID: 72828
CAS Number: CAS 90597-22-1
TTD Drug ID: DMAWVTX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting CTP synthase (CTPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acivicin	DMPQZ80	N. A.	N. A.	Discontinued in Phase 3	[3]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[4]
Cyclopentylcytosine	DM4KZ1W	Discovery agent	N.A.	Investigative	[2]
Carbodine	DMA3FZR	Discovery agent	N.A.	Investigative	[5]
Cylopentenyl cytosine	DMQWLIC	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CTP synthase (CTPS1)	TTN12BZ	PYRG1_HUMAN	Inhibitor	[2]

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References

1	Phase I clinical trial of continuous infusion cyclopentenyl cytosine. Cancer Chemother Pharmacol. 1995;36(6):513-23.
2	Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.
3	Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Sep;41(9 Pt 1):3419-23.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase. Mol Pharmacol. 1987 Aug;32(1):286-92.
6	Comments on: cylopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. A.C. Verschuur et al. Eur J Cancer 2000, 36, 627-635. Eur J Cancer. 2001 Jan;37(2):290.