Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAXEH3)

Drug Name
Methyl arachidonyl fluorophosphonate Drug Info
Synonyms
(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenyl methyl phosphorofluoridate; SCHEMBL177496; GTPL5218; methylarachidonoylflurophosphonate; methyl arachidonyl fluorophosphate; (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-yl methyl fluorophosphonate; Fluorophosphonic acid methyl(5Z,8Z,11Z,14Z)-5,8,11,14-icosatetrenyl ester
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
25021170
TTD Drug ID
DMAXEH3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cytosolic phospholipase A2 (GIVA cPLA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ZPL521 DMPZE2G Atopic dermatitis EA80 Phase 1/2 [3]
EFIPLADIB DMJ0A5U Asthma CA23 Terminated [4]
1,1,1-Trifluoro-7-phenylheptan-2-one DMLHVWP Discovery agent N.A. Investigative [5]
ARACHIDONYL TRIFLUOROMETHYLKETONE DMHL48F Discovery agent N.A. Investigative [2]
1,1,1-Trifluoro-8-phenyl-octan-2-one DMYENI7 Discovery agent N.A. Investigative [5]
AR-C70484XX DMU3A57 Discovery agent N.A. Investigative [6]
1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one DM3JHVL Discovery agent N.A. Investigative [6]
AX-006 DMDWCY7 Discovery agent N.A. Investigative [7]
N-(4-Ethoxybutyl)-2-oxohexadecanamide DM012TN Discovery agent N.A. Investigative [8]
[3,4''']biflavone DMHU4NS Discovery agent N.A. Investigative [9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cytosolic phospholipase A2 (GIVA cPLA2) TTT1JVS PA24A_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5218).
2 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G586-97.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. J Med Chem. 2009 Feb 26;52(4):1156-71.
5 Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37.
6 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52.
7 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 1;17(13):4833-43.
8 Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69.
9 Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Bioorg Med Chem. 2007 Nov 15;15(22):7138-43.