Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB0LSF)

Drug Name

ALMB-0168 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Osteosarcoma	2B51	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Granexin gel	DMZS2R7	Diabetic foot ulcer	BD54	Phase 3	[3]
Act1	DMXYRPO	Wound healing	EL8Y	Phase 3	[4]
HCB1019	DMX8C6J	Diabetic macular edema	9B71.02	Phase 2	[5]
ALMB-0166	DM3MH2H	Spinal cord injury	ND51.2	Phase 1	[6]
octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gap junction alpha-1 protein (GJA1)	TT4F7SL	CXA1_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04886765) A Phase I/II, Multi-center, Single-Arm, Open-Label Study to Evaluate the Safety and Efficacy of ALMB-0168 in Patients With Osteosarcoma. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of AlaMab Therapeutics
3	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4	Company report (FirstString Research)
5	Clinical pipeline report, company report or official report of OcuNexus Therapeutics.
6	Clinical pipeline report, company report or official report of AlaMab Therapeutics
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 728).