Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB7685)

Drug Name
EAPB0203 Drug Info
Synonyms
UNII-KXZ9LA2QV7; KXZ9LA2QV7; EAPB-0203; N-Methyl-1-(2-phenylethyl)imidazo(1,2-a)quinoxalin-4-amine; n-methyl-1-(2-phenylethyl)imidazo[1,2-a]quinoxalin-4-amine; CHEMBL488644; SCHEMBL2815787; EAPB 0203; Imidazo(1,2-a)quinoxalin-4-amine, N-methyl-1-(2-phenylethyl)-; 681284-86-6
Indication
Disease Entry ICD 11 Status REF
T-cell leukaemia 2A90 Investigative [1]
Cross-matching ID
PubChem CID
24779760
CAS Number
CAS 681284-86-6
TTD Drug ID
DMB7685

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Apoptosis regulator Bcl-xL (BCL-xL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABT-263 DMNE56X Myelofibrosis 2A20.2 Phase 3 [2]
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
APG-1252 DM8O3R9 Small-cell lung cancer 2C25.Y Phase 1/2 [4]
AZD0466 DMWLZI6 Hematologic tumour 2B33.Y Phase 1/2 [5]
PMID27744724-Compound-18 DM73S2C N. A. N. A. Patented [6]
Indole-based analog 2 DM0NEVC N. A. N. A. Patented [6]
PMID27744724-Compound-10 DMFKS2P N. A. N. A. Patented [6]
PMID27744724-Compound-21 DM18UA5 N. A. N. A. Patented [6]
Indole-based analog 3 DMTEYQJ N. A. N. A. Patented [6]
PMID27744724-Compound-26 DM8GOH3 N. A. N. A. Patented [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cellular inhibitor of apoptosis 1 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AT-406 DMVJW0S Squamous head and neck cell carcinom 2D60.0 Phase 3 [7]
Birinapant DM6PBUM Lymphoma 2A80-2A86 Phase 2 [8]
PMID25980951-Compound-6 DMVSW5N N. A. N. A. Patented [9]
PMID25980951-Compound-27 DMXAH9F N. A. N. A. Patented [9]
PMID25980951-Compound-43 DMTJRCS N. A. N. A. Patented [9]
PMID25980951-Compound-1 DMYPT2H N. A. N. A. Patented [9]
PMID25980951-Compound-44 DMS5896 N. A. N. A. Patented [9]
PMID25980951-Compound-3 DMPSWXU N. A. N. A. Patented [9]
PMID25980951-Compound-4 DM9RZSH N. A. N. A. Patented [9]
PMID25980951-Compound-21 DMIE0MR N. A. N. A. Patented [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apoptosis regulator Bcl-xL (BCL-xL) TTU1E82 B2CL1_HUMAN Inhibitor [1]
Cellular inhibitor of apoptosis 1 (BIRC2) TTQ5LRD BIRC2_HUMAN Inhibitor [1]

References

1 EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma. Blood. 2008 Apr 1;111(7):3770-7.
2 Clinical pipeline report, company report or official report of Roche (2009).
3 Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
4 Bcl-2/Bcl-xl inhibitor APG-1252-M1 is a promising therapeutic strategy for gastric carcinoma. Cancer Med. 2020 Jun;9(12):4197-4206.
5 Design and optimisation of dendrimer-conjugated Bcl-2/x L inhibitor, AZD0466, with improved therapeutic index for cancer therapy. Commun Biol. 2021 Jan 25;4(1):112.
6 Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.
7 Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51.
8 cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014 Apr 17;123(16):2562-72.
9 Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74.