General Information of Drug (ID: DMB9N4J)

Drug Name
ABT-957 Drug Info
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 1 [1]
Cross-matching ID
PubChem CID
67095330
TTD Drug ID
DMB9N4J

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Drug(s) Targeting Calpain-2 (CAPN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [3]
Epoxysuccinate derivative 9 DM49FU0 N. A. N. A. Patented [3]
Epoxysuccinate derivative 4 DMCF6M8 N. A. N. A. Patented [3]
Carboxamide derivative 7 DM8TQS4 N. A. N. A. Patented [3]
Epoxysuccinate derivative 7 DMTSPVF N. A. N. A. Patented [3]
Carboxamide derivative 10 DM5WMO9 N. A. N. A. Patented [3]
Carboxamide derivative 11 DM1DN94 N. A. N. A. Patented [3]
Carboxamide derivative 8 DM6HI34 N. A. N. A. Patented [3]
Epoxysuccinate derivative 10 DMYF39U N. A. N. A. Patented [3]
Carboxamide derivative 6 DM6GZW4 N. A. N. A. Patented [3]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calpain-2 (CAPN2) TTG5QB7 CAN2_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT02220738) Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ABT-957 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors. U.S. National Institutes of Health.
2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
3 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.