Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBDFN7)

Drug Name

GS-4977 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diabetic nephropathy	GB61.Z	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Apoptosis signal-regulating kinase 1 (MAP3K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GS-4997	DMNABMU	Diabetic nephropathy	GB61.Z	Phase 2	[2]
PMID23147077C10	DM3Z6F4	Discovery agent	N.A.	Investigative	[3]
MSC2032964A	DMS3O9H	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis signal-regulating kinase 1 (MAP3K5)	TTOQCD8	M3K5_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040265)
2	Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33.
3	Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9.
4	Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2(12):504-15.