Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBEHA5)

• Drug Name: PMID15724976C1 Drug Info
• Synonyms: AC1NQPIE; GTPL7507

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5276852
  TTD Drug ID: DMBEHA5

Molecule-Related Drug Atlas

Drug(s) Targeting Histone acetyltransferase KAT2B (KAT2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
garcinol	DM6B9ZG	Discovery agent	N.A.	Investigative	[2]
anacardic acid	DMAS5BI	Discovery agent	N.A.	Investigative	[3]
MB-3	DMNRMKA	Discovery agent	N.A.	Investigative	[4]
LTK-14	DMW09LB	Discovery agent	N.A.	Investigative	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone acetyltransferase KAT2B (KAT2B)	TTVK7SB	KAT2B_HUMAN	Inhibitor	[1]

References

• [1] Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc. 2005 Mar 2;127(8):2376-7.
• [2] Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene e... J Biol Chem. 2004 Aug 6;279(32):33716-26.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2737).
• [4] Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5. Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6.
• [5] Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol. 2007 Jun;14(6):645-57.