Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBKJL8)

• Drug Name: DIOA Drug Info
• Synonyms: dihydroindenyl-oxyalkanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5017
  CAS Number: CAS 106105-17-3
  TTD Drug ID: DMBKJL8

Molecule-Related Drug Atlas

Drug(s) Targeting Solute carrier family 12 member 5 (SLC12A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VU0240551	DMU3YRH	Discovery agent	N.A.	Investigative	[6]
CLP-635	DM1B0PY	Epilepsy	8A60-8A68	Investigative	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 12 member 4 (SLC12A4)	TTJ8C67	S12A4_HUMAN	Inhibitor	[2]
Solute carrier family 12 member 5 (SLC12A5)	TTH6UZY	S12A5_HUMAN	Inhibitor	[3]
Solute carrier family 12 member 6 (SLC12A6)	TT8DFHE	S12A6_HUMAN	Inhibitor	[4]
Solute carrier family 12 member 7 (SLC12A7)	TTU2PCD	S12A7_HUMAN	Inhibitor	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4589).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 971).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 972).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 973).
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 974).
• [6] Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8.