Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBLX7U)

Drug Name

Evinacumab Drug Info

Synonyms

REGN1500; ANGPTL-1 antibody

Indication

Disease Entry	ICD 11	Status	REF
Hypercholesterolaemia	5C80.0	Approved	[1]
Elevated C-reactive protein	MA14.15	Phase 2	[2]
Familial hypercholesterolemia	5C80.00	Phase 2	[3]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Angiopoietin-related protein 3 (ANGPTL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AKCEA-ANGPTL3-LRX	DMR8W7Y	Cardiovascular disease	BA00-BE2Z	Phase 2	[3]
LNA043	DMDHVK8	Knee osteoarthritis	FA01	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiopoietin-related protein 3 (ANGPTL3)	TTUO98L	ANGL3_HUMAN	Inhibitor	[1]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial. Nat Med. 2022 Dec;28(12):2633-2645.