Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBMKV8)

Drug Name
Disulfiram Drug Info
Synonyms
Abstenisil; Abstinil; Abstinyl; Alcophobin; Antabus; Antabuse; Antadix; Antaenyl; Antaethan; Antaethyl; Antaetil; Antalcol; Antetan; Antethyl; Antetil; Anteyl; Anthethyl; Antiaethan; Anticol; Antietanol; Antiethanol; Antietil; Antikol; Antivitium; Aversan; Averzan; Bonibal; Contralin; Contrapot; Cronetal; Dicupral; Disetil; Disulfan; Disulfirame; Disulfiramo; Disulfiramum; Disulfirm; Disulfram; Disulfuram; Disulphuram; Ephorran; Espenal; Esperal; Etabus; Ethyldithiourame; Ethyldithiurame; Exhoran; Exhorran; Gababentin; Hoca; Krotenal; Nocbin; Nocceler; Noxal; Refusal; Stopaethyl; Stopethyl; Stopety; Stopetyl; TATD; TETD; THIOCID; TTD; TTS; Tenurid; Tenutex; Tetidis; Tetradin; Tetradine; Tetraethylthiuram; Tetraetil; Teturam; Teturamin; Thireranide; Thiuranide; Tillram; Tiuram; Accel TET; Akrochem TETD; Ancazide ET; Antab use; Disulfirame [DCIT]; Ekagom DTET; Ekagom TEDS; Ekagom TETDS; Ekaland TETD; Esperal [France]; Eta bus; Ethyl Thiram; Ethyl Thiudad; Ethyl Thiurad; Ethyl Tuads Rodform; Ethyl Tuex; Ethyl tuads; Etyl Tuex; Nocceler TET; Perkacit TETD; Perkait TETD; Robac TET; Sanceler TET; Soxinol TET; TTS x; Tet raethylthiuram; Thiuram E; Dupon 4472; T 1132; Accel TET-R; Alk-aubs; Antabus (TN); Antabuse (TN); Anti-ethyl; Antivitium (Spain); ENT 27,340; Nocceler TET-G; Noxal (VAN); Ro-sulfiram; Sanceler TET-G; Tuads, ethyl; Usaf B-33; Ro-Sulfram-500 (USA)
Indication
Disease Entry ICD 11 Status REF
Alcohol dependence 6C40.2 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [3]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [3]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
3117
ChEBI ID
CHEBI:4659
CAS Number
CAS 97-77-8
TTD Drug ID
DMBMKV8
ACDINA Drug ID
D00206

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Preclinical Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting MERS-CoV papain-like proteinase (PL-PRO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thioguanine DM7RMG9 Acute lymphocytic leukaemia 2B33.3 Preclinical [4]
Mercaptopurine DMTQXS7 Acute lymphocytic leukaemia 2B33.3 Preclinical [4]
PMID30940566-compound-6 DMXCKL9 Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [5]
Mycophenolic acid DMU65NK Crohn disease DD70 Investigative [6]
Drug(s) Targeting COVID-19 papain-like proteinase (PL-PRO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DMBJTVL Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [7]
SPI-1005 DM26AHR Meniere disease AB31.0 Phase 2 [2]
PMID26868298-compound-N3 DMQFUCD Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [2]
GRL0617 DMX9AGF Coronavirus infection 1D92 Preclinical [8]
PX-12 DM9JYF3 Pancreatic cancer 2C10 Investigative [2]
Hexylcarbamoyl fluorouracil DM3YFG9 Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Isoarnebin 4 DM0B7NO Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Tideglusib DM71HQL Alzheimer disease 8A20 Investigative [2]
PMID32321856-compound-11a DMN39V6 Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [9]
PMID32321856-compound-11b DM31QEY Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting SARS-CoV papain-like proteinase (PL-PRO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thioguanine DM7RMG9 Acute lymphocytic leukaemia 2B33.3 Preclinical [4]
Mercaptopurine DMTQXS7 Acute lymphocytic leukaemia 2B33.3 Preclinical [4]
GRL-0667 DML09OS Severe acute respiratory syndrome (SARS) 1D65 Investigative [10]
PMID20527968-compound-6577871 DMI30V7 Severe acute respiratory syndrome (SARS) 1D65 Investigative [10]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
COVID-19 papain-like proteinase (PL-PRO) TTNHMO8 R1AB_SARS2 (819-2763) Inhibitor [2]
MERS-CoV papain-like proteinase (PL-PRO) TTYJOLE R1AB_CVEMC (854-2740) Inhibitor [3]
SARS-CoV papain-like proteinase (PL-PRO) TTRGHB2 R1AB_CVHSA (819-2740) Inhibitor [3]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9.
3 Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.
4 Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16.
5 Identification and Design of Novel Small Molecule Inhibitors Against MERS-CoV Papain-Like Protease via High-Throughput Screening and Molecular Modeling Bioorg Med Chem. 2019 May 15;27(10):1981-1989.
6 SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016 Aug;14(8):523-34.
7 ClinicalTrials.gov (NCT04361422) Isotretinoin in Treatment of COVID-19. U.S. National Institutes of Health.
8 Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B. 2021 Jan;11(1):237-245.
9 Structure-based Design of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. Science. 2020 Apr 22;eabb4489.
10 Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biologic... J Med Chem. 2010 Jul 8;53(13):4968-79.