General Information of Drug (ID: DMBN6W2)

Drug Name
US10035778, Example 12 Drug Info
Synonyms
SCHEMBL19067109; BDBM279571; US10035778, Example 12; Preparation of (3S)-3-[3-chloro-5-methyl-phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid
Cross-matching ID
PubChem CID
130177126
TTD Drug ID
DMBN6W2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Drug(s) Targeting Integrin beta-8 (ITGB8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MEDI8367 DM7L053 Chronic kidney disease GB61 Phase 1 [2]
US10035778, Example 16 DMJ53DR N. A. N. A. Patented [1]
US10035778, Example 1 DM28XHN N. A. N. A. Patented [1]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin beta-8 (ITGB8) TTIF29E ITB8_HUMAN Inhibitor [1]

References

1 Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists. US10035778.
2 ClinicalTrials.gov (NCT04365218) A Phase I Randomized, Blinded, Placebo-controlled Study to Evaluate the Safety and Pharmacokinetics of MEDI8367 Administered as Single Ascending Doses in Healthy Subjects, and as a Single Dose in Healthy Subjects of Japanese-descent and in Subjects With Chronic Kidney Disease. U.S.National Institutes of Health.