Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBNDYK)

Drug Name

AVP-13748 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune disease	4A40-4A45	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[2]
Anti-MIF antibodies	DM8EKSV	Autoimmune diabetes	5A10	Phase 4	[3]
ISO-1	DMDB7KU	N. A.	N. A.	Phase 1	[4]
COR100140	DMN0GTR	Inflammation	1A00-CA43.1	Preclinical	[5]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE	DMPSOIF	Discovery agent	N.A.	Investigative	[6]
4-hydroxyphenylpyruvic acid	DM0564K	Discovery agent	N.A.	Investigative	[6]
AVP-13546	DMDTONZ	Autoimmune disease	4A40-4A45	Investigative	[1]
4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME	DM7WPGN	Discovery agent	N.A.	Investigative	[6]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Macrophage migration inhibitory factor (MIF)	TT2AST1	MIF_HUMAN	Inhibitor	[1]

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References

1	MIF in autoimmunity and novel therapeutic approaches. Autoimmun Rev. 2009 Jan;8(3):244-9.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the beta-Sheet Structure of MIF. J Biol Chem. 2012 March 2; 287(10): 7446-7455.
4	The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.
5	Cortical Pty Ltd Presents MIF Antagonist Data at World Congress on Inflammation. Cortical Pty Ltd. 2005.
6	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.