Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBNFQ8)

Drug Name

D-lactic acid Drug Info

Synonyms

R-lactic acid; D-lactate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting G protein coupled receptor 81 (HCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-lactic acid	DMO1Z5Q	Discovery agent	N.A.	Investigative	[4]
3,5-dihydroxybenzoic acid	DM04N7I	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G protein coupled receptor 81 (HCAR1)	TTVK4ZO	HCAR1_HUMAN	Agonist	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Lactate racemase (Lsa784)^{Main DME}	DEINPMH	Q3BCH3_LACSK	Substrate	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2934).
2	Role of GPR81 in lactate-mediated reduction of adipose lipolysis. Biochem Biophys Res Commun. 2008 Dec 19;377(3):987-91.
3	The effect of sodium acetate on the growth yield, the production of L- and D-lactic acid, and the activity of some enzymes of the glycolytic pathway of Lactobacillus sakei NRIC 1071(T) and Lactobacillus plantarum NRIC 1067(T). J Gen Appl Microbiol. 2002 Apr;48(2):91-102.
4	Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609.
5	3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther. 2012 Jun;341(3):794-801.