Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBPUIK)

Drug Name
BXCL701 Drug Info
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMBPUIK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Dipeptidyl peptidase 8 (DPP-8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talabostat DM1IZ5D Constitutional neutropenia 4B00.0 Phase 3 [3]
Thiomorpholine derivative 1 DMZP6KR N. A. N. A. Patented [4]
Thiomorpholine derivative 2 DMWOK1D N. A. N. A. Patented [4]
PMID20684603C24dd DMWZK9U Discovery agent N.A. Investigative [5]
1G244 DMEB8CG Discovery agent N.A. Investigative [6]
PMID15664838C18 DM93RKC Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Targeting Dipeptidyl peptidase 9 (DPP-9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talabostat DM1IZ5D Constitutional neutropenia 4B00.0 Phase 3 [3]
Thiomorpholine derivative 1 DMZP6KR N. A. N. A. Patented [4]
Thiomorpholine derivative 2 DMWOK1D N. A. N. A. Patented [4]
PMID20684603C24dd DMWZK9U Discovery agent N.A. Investigative [5]
1G244 DMEB8CG Discovery agent N.A. Investigative [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dipeptidyl peptidase 8 (DPP-8) TTJGLZF DPP8_HUMAN Inhibitor [2]
Dipeptidyl peptidase 9 (DPP-9) TTNDUL7 DPP9_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT03910660) Phase 1b/2 Study of BXCL701, a Small Molecule Inhibitor of Dipeptidyl Peptidases, Administered in Combination With the Anti-Programmed Cell Death 1 Monoclonal Antibody Pembrolizumab in Patients With mCRPC Either Small Cell Neuroendocrine Prostate Cancer or Adenocarcinoma Phenotype. U.S.National Institutes of Health.
2 DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma. J Immunother Cancer. 2021 Nov;9(11):e002837.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36.
5 Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem. 2010 Aug 12;53(15):5620-8.
6 Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem Pharmacol. 2009 Jul 15;78(2):203-10.
7 Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg Med Chem Lett. 2005 Feb 1;15(3):687-91.