General Information of Drug (ID: DMBWPZJ)

Drug Name
GSK2245035 Drug Info
Synonyms GSK-2245035
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Phase 2 [1]
Cross-matching ID
PubChem CID
44623937
CAS Number
CAS 1207629-49-9
TTD Drug ID
DMBWPZJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Toll-like receptor 7 (TLR7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [3]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [4]
ANA773 DMSC8YW Hepatitis C virus infection 1E51.1 Phase 2a [5]
GS-9620 DMG5C8D Hepatitis B virus infection 1E51.0 Phase 2 [6]
IMO-3100 DMM549D Psoriasis vulgaris EA90 Phase 2 [7]
Resiquimod DML6XSP Actinic keratosis EK90.0 Phase 2 [8]
LOXORIBINE DMIV9ZE Immune System disease 4A01-4B41 Phase 2 [9]
AZD-8848 DM0M7QW Allergic rhinitis CA08.0 Phase 2 [10]
Isatoribine DMHOJ8W Hepatitis C virus infection 1E51.1 Phase 2 [11]
PF-4878691 DM24I0N Melanoma 2C30 Phase 2 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 7 (TLR7) TTRJ1K4 TLR7_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT01607372) A Study to Investigate the Safety, Pharmacodynamics and Efficacy Against Allergic Reactivity of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies. U.S. National Institutes of Health.
2 Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement. Clin Pharmacol Ther. 2015 Oct;98(4):369-80.
3 Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov;129(11):2676-85.
4 TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets. 2007 Dec;6(4):223-35.
5 Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
6 Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses. J Pharmacol Exp Ther. 2014 Jan;348(1):96-105.
7 Company report (Iderapharma)
8 TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).Vaccine.2005 Nov 1;23(45):5263-70.
9 The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97.
10 Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respir Res. 2012 Jun 22;13:53.
11 Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40.
12 The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.