Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBZTS5)

• Drug Name: Alpha-ketoisovalerate Drug Info
• Synonyms: 3-Methyl-2-oxobutanoic acid; 759-05-7; 3-methyl-2-oxo-butanoic acid; alpha-Ketoisovalerate; alpha-Ketoisovaleric acid; 2-Ketoisovaleric acid; alpha-ketovaline; 2-oxoisovalerate; 3-Methyl-2-oxobutyric acid; Butanoic acid, 3-methyl-2-oxo-; 2-Oxoisovaleric acid; 2-ketovaline; 3-methyl-2-oxobutanoate; 2-keto-3-methylbutyric acid; 2-oxo-3-methylbutanoate; 2-oxoisopentanoate; alpha-oxoisovalerate; Dimethylpyruvic acid; a-ketoisovaleric acid; KETOVALINE; Isopropylglyoxylic acid; alpha-keto-isovaleric acid; 2-Oxo-3-methylbutanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 49
  ChEBI ID: CHEBI:16530
  CAS Number: CAS 759-05-7
  TTD Drug ID: DMBZTS5

Molecule-Related Drug Atlas

Drug(s) Targeting Branched-chain-amino-acid transaminase 2 (BCAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyridoxamine-5'-Phosphate	DMQ6POC	Discovery agent	N.A.	Investigative	[1]
N-[O-Phosphono-Pyridoxyl]-Isoleucine	DM6EICU	Discovery agent	N.A.	Investigative	[1]
N'-(phenylsulfonyl)benzofuran-2-carbohydrazide	DMJO3B1	Discovery agent	N.A.	Investigative	[2]
N'-(phenylsulfonyl)quinoline-6-carbohydrazide	DMQETUY	Discovery agent	N.A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Branched-chain-amino-acid transaminase 2 (BCAT2)	TTF9OQ6	BCAT2_HUMAN	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40.