Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC15DM)

Drug Name

Amooranin Drug Info

Synonyms

MCH-100XC2; Caspase-8 stimulator/apoptosis stimulator/cell cycle inhibitor (cancer), Dharma Biomedical; P-glycoprotein modulator (small molecule therapeutic/natural product, cancer/autoimmune diseases/inflammatory diseases), Dharma BioMedical

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Investigative	[1]

Cross-matching ID

PubChem CID: 11503749
TTD Drug ID: DMC15DM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glionitrin A	DM98CSW	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
Acetyl-Ile-Glu-Thr-Asp-aldehyde	DM1VE6S	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Caspase-8 (CASP8)	TTEVCT0	CASP8_HUMAN	Inhibitor	[1]

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References

1	Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378-86.
2	The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure. 1999 Sep 15;7(9):1135-43.