Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC4UHD)

Drug Name
PF-543 Drug Info
Synonyms sphingosine kinase 1 Inhibitor II; PF 543
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
66577038
ChEBI ID
CHEBI:131144
CAS Number
CAS 1415562-82-1
TTD Drug ID
DMC4UHD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Sphingosine kinase 1 (SPHK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxodiol DMBUJVX Ovarian cancer 2C73 Phase 1/2 [3]
GSK618334 DMJPXZ4 Drug abuse 6C4G.1Z Phase 1 [4]
PMID27539678-Compound-6 DMBKNDE N. A. N. A. Patented [5]
Methylbenzenesulfonamide derivative 1 DMUNME2 N. A. N. A. Patented [5]
PMID27539678-Compound-12 DMNIKTA N. A. N. A. Patented [5]
PMID27539678-Compound-10 DM61SR0 N. A. N. A. Patented [5]
PMID27539678-Compound-16 DMMDJH8 N. A. N. A. Patented [5]
PMID27539678-Compound-14 DMZ02LA N. A. N. A. Patented [5]
PMID27539678-Compound-13 DM1J2V8 N. A. N. A. Patented [5]
PMID27539678-Compound-11 DMIKAJC N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine kinase 1 (SPHK1) TTOHFIY SPHK1_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6623).
2 Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.Oncotarget. 2016 Dec 6;7(49):80586-80598.
5 Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416.