Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC5SAW)

Drug Name

LY3039478 Drug Info

Synonyms

LY3039478; Crenigacestat; 1421438-81-4; LY-3039478; UNII-923X28214S; 4,4,4-Trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide; 923X28214S; butanamide, n-[(1s)-2-[[(7s)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5h-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluoro-; Butanamide, N-((1S)-2-(((7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido(3,2-a)(3)benzazepin-7-yl)amino)-1-methyl-2-oxoethyl)-4,4,4-trifluoro-

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
T-cell acute lymphoblastic leukaemia	2A90.5	Phase 1/2	[2]
Lymphoma	2A80-2A86	Phase 1	[3]

Cross-matching ID

PubChem CID: 71236992
CAS Number: CAS 1421438-81-4
TTD Drug ID: DMC5SAW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Notch-1 receptor (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OMP-52M51	DMGWC86	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Notch-1 receptor (NOTCH1)	TTB1STW	NOTC1_HUMAN	Inhibitor	[2]
Notch-4 receptor (NOTCH4)	TTXDIK2	NOTC4_HUMAN	Inhibitor	[4]

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References

1	ClinicalTrials.gov (NCT02784795) A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	ClinicalTrials.gov (NCT01695005) A Study of LY3039478 in Participants With Advanced Cancer. U.S. National Institutes of Health.
4	J Clin Oncol 33, 2015 (suppl; abstr 2533).
5	National Cancer Institute Drug Dictionary (drug id 741867).