Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC70P1)

Drug Name

3-hydroxy capric acid Drug Info

Synonyms

3-OH-C10; 3-hydroxy-decanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Inflammation-related GPCR EX33 (GPR84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PBI-4050	DMPXK27	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[3]
SHR0534	DMGFTAI	Type 2 diabetes	5A11	Phase 1	[4]
2-hydroxy capric acid	DMJAN52	Discovery agent	N.A.	Investigative	[2]
6-n-octylaminouracil	DMXJFCQ	Discovery agent	N.A.	Investigative	[2]
3-hydroxylauric acid	DMNMB6V	Discovery agent	N.A.	Investigative	[2]
2-hydroxylauric acid	DMCNW3M	Discovery agent	N.A.	Investigative	[2]
undecanoic acid	DMFOIPL	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inflammation-related GPCR EX33 (GPR84)	TTG0MQD	GPR84_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5848).
2	Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91.
3	Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis. Eur Respir J. 2019 Mar 18;53(3):1800663.
4	Targeting metabolic dysregulation for fibrosis therapy. Nat Rev Drug Discov. 2020 Jan;19(1):57-75.
5	Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem. 2006 Nov 10;281(45):34457-64.