Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC8G4S)

Drug Name

PF-4181366 Drug Info

Synonyms

PDE9A inhibitor (cognitive deficit), Pfizer

Indication

Disease Entry	ICD 11	Status	REF
Cognitive impairment	6D71	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Phosphodiesterase 9 (PDE9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-4447943	DM81D4I	Alzheimer disease	8A20	Phase 2	[2]
ASP-4901	DMZUAH2	Genitourinary disease	GA0Z-GC8Z	Phase 2	[3]
E2027	DMK8SY6	Lewy body dementia	6D82	Phase 2	[4]
BI-409306	DMJFDS0	Alzheimer disease	8A20	Phase 2	[5]
IMR-687	DM15MRZ	Sickle-cell disorder	3A51	Phase 2	[6]
CRD-740	DMRTX0K	Heart failure	BD10-BD13	Phase 2	[7]
TT-00920	DMP6G0P	Heart failure	BD10-BD13	Phase 1	[8]
SCH51866	DMCWSJP	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309).
2	A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor, PF-04447943, in Alzheimer's disease. Curr Alzheimer Res. 2014;11(5):413-21.
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033070)
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Clinical pipeline report, company report or official report of Boehringer Ingelheim pipeline.
6	Clinical pipeline report, company report or official report of Imara.
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
8	Clinical pipeline report, company report or official report of TransThera Biosciences
9	Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64.